Most recently, Botox was approved by the FDA for prevention of chronic migraine headaches. It is an injectable drug and no pill form is available. It is injected approximately every 3 months around the head and neck region. It does not seem to work as well for headaches occurring less than 14 days per month. The drug is made by the company Allergan, and in 2 studies funded by the company, it showed a modest benefit. Keep in mind though that it requires injecting the drug by an experienced physician. Ironically, the most common side effects experienced are neck pain and headache. In some patients, Botox can be very effective when all other drugs have not produced significant relief of the pain.